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The acronym HIV PrEP stands for "Pre-exposure prophylaxis." This term refers to a preventive strategy for individuals who are at high risk of contracting HIV. PrEP involves the daily use of antiretroviral medication to significantly reduce the risk of HIV infection if someone is exposed to the virus. This option accurately captures the essence of what PrEP is designed to do in the context of HIV prevention.

In contrast, the other options do not accurately reflect the medical and preventive purpose of PrEP. For instance, post-exposure prevention refers to measures taken after potential exposure to HIV, which is not the focus of PrEP. Similarly, primary exposure protection and periodic risk evaluation plan do not align with HIV prevention strategies in the same way that Pre-exposure prophylaxis does. Understanding PrEP as a preemptive approach is crucial for recognizing its role in reducing HIV transmission among high-risk populations.